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  • Title: Synthesis and antibacterial activity of [6,5,5] and [6,6,5] tricyclic fused oxazolidinones.
    Author: Gleave DM, Brickner SJ, Manninen PR, Allwine DA, Lovasz KD, Rohrer DC, Tucker JA, Zurenko GE, Ford CW.
    Journal: Bioorg Med Chem Lett; 1998 May 19; 8(10):1231-6. PubMed ID: 9871741.
    Abstract:
    A series of conformationally restricted, [6,5,5] and [6,6,5] tricyclic fused oxazolidinones were synthesized and tested for antibacterial activity. Several compounds in the trans-[6,5,5] series demonstrated potent in vitro and in vivo activity. This work provides valuable information regarding the preferred conformational orientation of the oxazolidinones at the binding site.
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