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  • Title: 1,2-disubstituted cyclohexane derived tripeptide aldehydes as novel selective thrombin inhibitors.
    Author: Harmat NJ, Di Bugno C, Criscuoli M, Giorgi R, Lippi A, Martinelli A, Monti S, Subissi A.
    Journal: Bioorg Med Chem Lett; 1998 May 19; 8(10):1249-54. PubMed ID: 9871744.
    Abstract:
    A series of tripeptide arginine aldehydes was synthesized by replacement of proline with 1,2-disubstituted cyclohexane derivatives in the sequence of D-MePhe-Pro-Arg-H. Based on molecular modeling, further modification of the D-MePhe residue resulted in a potent and selective thrombin inhibitor.
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