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  • Title: The novel cyclopropapyrroloindole(CPI) bisalkylators bearing methoxycarbonyl and trifluoromethyl groups.
    Author: Fukuda Y, Furuta H, Kusama Y, Ebisu H, Oomori Y, Terashima S.
    Journal: Bioorg Med Chem Lett; 1998 Jun 02; 8(11):1387-90. PubMed ID: 9871771.
    Abstract:
    The novel 3-methoxycarbonyl-2-trifluoromethylcyclopropapyrroloindole (MCTFCPI) bisalkylators were synthesized and their antitumor activity was evaluated. Among these derivatives, 7f in which two MCTFCPI moieties are connected with a 5,5'-bis(2-carbonyl-1H-indole) group, was found to exhibit more prominent cytotoxicity and antitumor activity than U-77,779 (bizelesin) (2).
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