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  • Title: Novel constrained CCK-B dipeptoid antagonists derived from pipecolic acid.
    Author: Bellier B, Da Nascimento S, Meudal H, Gincel E, Roques BP, Garbay C.
    Journal: Bioorg Med Chem Lett; 1998 Jun 02; 8(11):1419-24. PubMed ID: 9871777.
    Abstract:
    A new series of 4-substituted pipecolic acid derivatives was prepared and incorporated into dipeptoids. The resulting products behave as moderately potent CCK-B antagonists but their constrained structure and its comparison with structurally related compounds yield valuable information about the conformational requirements for optimal recognition of the CCK-B receptor by antagonists.
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