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  • Title: Peptidyl chemosensors incorporating a FRET mechanism for detection of Ni(II).
    Author: Pearce DA, Walkup GK, Imperiali B.
    Journal: Bioorg Med Chem Lett; 1998 Aug 04; 8(15):1963-8. PubMed ID: 9873467.
    Abstract:
    Hexapeptides incorporating two fluorophores flanking a tripeptide sequence that binds Ni(II) and Cu(II) with high affinity have been synthesized. While Cu(II) quenches the fluorescence of the resulting peptides, coordination of Ni(II) enables enhanced FRET (fluorescent resonance energy transfer) from one fluorophore to the other.
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