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Title: Synthesis of novel substituted pyridines as inhibitors of endothelin converting enzyme-1 (ECE-1). Author: Massa MA, Patt WC, Ahn K, Sisneros AM, Herman SB, Doherty A. Journal: Bioorg Med Chem Lett; 1998 Aug 18; 8(16):2117-22. PubMed ID: 9873497. Abstract: A series of bi-aryl pyridine carboxylic acids has been prepared and evaluated as inhibitors of ECE-1. The analogs were prepared by Pd catalyzed cross couplings of halogenated pyridines with heteroaryl organo-boranes, -tinate or -zincate derivatives.[Abstract] [Full Text] [Related] [New Search]