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  • Title: Highly efficient and versatile synthesis of libraries of constrained beta-strand mimetics.
    Author: Ogbu CO, Qabar MN, Boatman PD, Urban J, Meara JP, Ferguson MD, Tulinsky J, Lum C, Babu S, Blaskovich MA, Nakanishi H, Ruan F, Cao B, Minarik R, Little T, Nelson S, Nguyen M, Gall A, Kahn M.
    Journal: Bioorg Med Chem Lett; 1998 Sep 08; 8(17):2321-6. PubMed ID: 9873535.
    Abstract:
    The general approach of using a bicyclic template to produce inhibitors of the protease superfamily of enzymes has been investigated. The Diels Alder cycloaddition reaction on solid support has been found to be highly efficient for the synthesis of libraries of compounds that mimic the beta-strand secondary structure of proteins. Several potent and selective inhibitors of proteases have been discovered.
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