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  • Title: Aryl sulfonamides as selective PDE4 inhibitors.
    Author: Montana JG, Buckley GM, Cooper N, Dyke HJ, Gowers L, Gregory JP, Hellewell PG, Kendall HJ, Lowe C, Maxey R, Miotla J, Naylor RJ, Runcie KA, Tuladhar B, Warneck JB.
    Journal: Bioorg Med Chem Lett; 1998 Oct 06; 8(19):2635-40. PubMed ID: 9873594.
    Abstract:
    A series of novel selective phosphodiesterase 4 (PDE4) inhibitors has been developed which displays activity both in vitro and in vivo. These compounds possess good selectivity for the catalytic site of PDE4 over the high affinity Rolipram binding site. In vivo studies demonstrate a reduced propensity to display the emetic side effects which are commonly observed with PDE4 inhibitors.
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