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  • Title: Synthesis and antibacterial activity of novel 7-(3-substituted-3 or 4-trifluoromethyl-1-pyrrolidinyl)-8-methoxyfluoroquinolones.
    Author: Fukui H, Shibata T, Naito T, Nakano J, Maejima T, Senda H, Iwatani W, Tatsumi Y, Suda M, Arika T.
    Journal: Bioorg Med Chem Lett; 1998 Oct 20; 8(20):2833-8. PubMed ID: 9873632.
    Abstract:
    The titled compounds were synthesized and evaluated for in vitro antibacterial activity. The (3R, 4S)-3-aminomethyl-4-trifluoromethyl derivative (S-34109) was confirmed to be optimal because of its superior activity against quinolone and methicillin-resistant Staphylococcus aureus and low side effect potential.
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