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  • Title: Rational design of a new series of mixed anti-HIV pronucleotides.
    Author: Schlienger N, Beltran T, Périgaud C, Lefebvre I, Pompon A, Aubertin AM, Gosselin G, Imbach JL.
    Journal: Bioorg Med Chem Lett; 1998 Nov 03; 8(21):3003-6. PubMed ID: 9873664.
    Abstract:
    MonoSATE aryl phosphotriesters of AZT are able to deliver intracellularly the corresponding 5'-mononucleotide. This process requires activation by an esterase followed by a phosphodiesterase. This finding opens the way to the design of new pronucleotide series.
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