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  • Title: Evaluation of dosage forms. IV. Studies on commercial phenylbutazone tablet dosage forms.
    Author: Razdan B, Paradkar AR.
    Journal: Drug Dev Ind Pharm; 1998 Jul; 24(7):599-604. PubMed ID: 9876503.
    Abstract:
    In order to determine the feasibility of dissolution-dialysis as a suitable technique for in vitro evaluation, studies on commercial phenylbutazone tablets were carried out. Although disintegration time and dissolution parameters did not give a true indication of bioavailability, an excellent correlation was obtained between the dialysis rate constant (K) and various pharmacokinetic parameters obtained from bioavailability studies on human volunteers.
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