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  • Title: Study of standard tablet formulation based on fluidized-bed granulation.
    Author: Sunada H, Hasegawa M, Makino T, Sakamoto H, Fujita K, Tanino T, Kokubo H, Kawaguchi T.
    Journal: Drug Dev Ind Pharm; 1998 Mar; 24(3):225-33. PubMed ID: 9876579.
    Abstract:
    In this study, acetaminophen, ascorbic acid, and ethenzamide were selected as model drugs for tableting granules. Agitation and fluidized-bed granulation were carried out at three drug contents of 30, 50, and 70%. Compared with agitation granulation, granules made by fluidized-bed granulation showed superior compressibility with wide formulation allowance for drug type and amount. Fluidized-bed granulation resulted in less granule hardness and greater plastic deformability. The granules had considerable compactness and for tablets containing 70% ethenzamide, prolonged disintegration and dissolution times were noted. These are typical features of granules produced by fluidized-bed granulation.
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