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  • Title: Alternative solvent-free preparation methods for felodipine surface solid dispersions.
    Author: Kerc J, Srcic S, Kofler B.
    Journal: Drug Dev Ind Pharm; 1998 Apr; 24(4):359-63. PubMed ID: 9876596.
    Abstract:
    Surface solid dispersions were prepared via physical mixture and were either heated in a vacuum dryer or in a microwave oven for different periods of time. The physical state of felodipine in solid dispersions was studied using differential scanning calorimetry and x-ray powder diffractometry. USP paddle method was used for felodipine dissolution studies. The use of vacuum or microwave energy led to a significant improvement of felodipine dissolution which was caused partly by the amorphous state of felodipine and a large surface area of amorphous silicon dioxide.
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