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  • Title: Contraction of detergent-treated smooth muscle.
    Author: Gordon AR.
    Journal: Proc Natl Acad Sci U S A; 1978 Jul; 75(7):3527-30. PubMed ID: 98770.
    Abstract:
    After exposure of segments of rabbit taenia coli to the nonionic detergent Triton X-100, tension could be induced by increasing the [Ca2+] in the micromolar range. In the presence of a saturating [Ca2+], this preparation developed nearly 100% of the control tetanus tension recorded from the intact muscle prior to the detergent treatment. In addition, tension could be induced by increasing the [Mg2+], in the virtual absence of Ca2+. Mg2+ seems to inhibit the Ca2+-induced tension in a predominantly competitive manner.
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