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  • Title: Sodium nitroprusside-induced hypotension for supine total hip replacement.
    Author: Lawson NW, Thompson DS, Nelson CL, Flacke JW, North ER.
    Journal: Anesth Analg; 1976; 55(5):654-62. PubMed ID: 987721.
    Abstract:
    Deliberate hypotension was produced during general anesthesia by the infusion of sodium nitroprusside in 13 patients undergoing total hip replacement. Hemodynamic data from these patients were compared with those obtained from 5 patients under normotensive anesthesia for the same procedure. During the hypotensive period, which averaged 1.5 hours, the cardiac index rose 20 percent compared with controls. No acidotic tendency was seen. Blood loss in the study group averaged 475 ml, compared with 1475 ml in controls. From these data, a dose-response curve was derived which may allow the accurate prediction of the minute dosage of sodium nitroprusside required to safely induce hypotension during anesthesia.
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