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  • Title: Effects of adenosine and epidermal growth factor on the growth of mouse mammary epithelial cells.
    Author: Yuh IS, Jang BB, Hong BJ.
    Journal: Cell Biol Int; 1998; 22(2):131-5. PubMed ID: 9878100.
    Abstract:
    The objective of this study was to determine if adenosine alters growth of mammary epithelium. Mouse mammary epithelial cells (NMuMG) were cultured in DMEM supplemented with 10% fetal calf serum. After serum starvation for 24 h, EGF (0-100 ng/ml) and/or adenosine (0-100 microM) was added. Adenosine at concentrations of 1, 10 or 100 microM increased DNA synthesis significantly, when compared to control. Addition of epidermal growth factor (EGF) (10 ng/ml) into 1 or 10 microM adenosine showed the interaction in DNA synthesis between EGF and adenosine. A similar result was observed when 100 microM adenosine added to various concentrations of EGF (0-100 ng/ml). In the second mammary gland (thoracic) organ culture studies, mammary development scores were increased by adenosine (100 microM), EGF (100 ng/ml) and adenosine plus EGF. These results indicate that the purine nucleoside adenosine stimulates mammary epithelial cell growth and interacts with EGF in DNA synthesis of mouse mammary epithelial cells.
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