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  • Title: Identification of domains involved in superantigenicity of streptococcal pyrogenic exotoxin F (SpeF).
    Author: Eriksson A, Holm SE, Norgren M.
    Journal: Microb Pathog; 1998 Nov; 25(5):279-90. PubMed ID: 9878456.
    Abstract:
    A series of 11 synthetic peptides of 30 amino acids, each with 10 amino acids overlap which spanned the entire sequence of streptococcal pyrogenic exotoxin F (SpeF), were employed in proliferation studies on human peripheral blood mononuclear cells (PBMCs). Regions 41-70, 141-170 and 181-210 were identified as important for SpeF-induced lymphocyte activation. Secondary structure predictions of these peptides showed similarities to regions in other superantigens known to be important for T cell mitogenicity. Furthermore, antisera specific to peptides covering amino acids 1-70 and 181-228 were able to inhibit SpeF-induced mitogenicity by 25% when pre-incubated with SpeF prior to PBMC activation.
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