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  • Title: Diversity and complexity of ceramide signalling in apoptosis.
    Author: Okazaki T, Kondo T, Kitano T, Tashima M.
    Journal: Cell Signal; 1998 Nov; 10(10):685-92. PubMed ID: 9884019.
    Abstract:
    Sphingolipid ceramide has emerged as a lipid messenger of cell functions including differentiation and apoptosis. Diverse kinds of stresses (ultraviolet, irradiation, heat shock and hypoxia) and biological factors (TNF-alpha, IFN-gamma and Fas antibody) require ceramide generation to execute apoptosis. The review summarises the diversity and complexity of up- and downstream of ceramide signalling in apoptosis and clinical implications of ceramide-induced apoptosis.
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