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  • Title: Mesalazine-associated severe aplastic anemia successfully treated with antithymocyte globulin, cyclosporine and granulocyte colony-stimulating factor.
    Author: Otsubo H, Kaito K, Sekita T, Shimada T, Kobayashi M, Hosoya T.
    Journal: Int J Hematol; 1998 Dec; 68(4):445-8. PubMed ID: 9885444.
    Abstract:
    A 20-year-old male with ulcerative colitis complicated by mesalazine-associated severe aplastic anemia is described. The patient developed aplastic anemia four months after the start of mesalazine therapy. He was treated with antithymocyte globulin, cyclosporine, and granulocyte colony-stimulating factor (G-CSF) and responded well. Hematological complications of mesalazine are rare, but if bone marrow suppression is detected, immediate cessation of the drug and intensive immunosuppressive treatment with G-CSF should be considered.
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