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  • Title: Lymphomatoid granulomatosis of the lung: a clinico-pathological study.
    Author: Baldi A, Groeger AM, Esposito V, Di Lieto E, Di Marino MP, Santini D, Baldi F.
    Journal: Anticancer Res; 1998; 18(6B):4621-4. PubMed ID: 9891529.
    Abstract:
    Lymphomatoid granulomatosis is the only form of pulmonary angiitis histologically characterized by a necrotizing angiocentric and angiodestructive lymphoid infiltrate, with an admixed T-cell reaction. We evaluated three patients with a single lung nodule not diagnosed by routine radiological and endoscopic assays. Our investigations showed a prevalence of T-cells in areas of diffuse infiltration, which were actively replacing reactive follicular areas of B-cells, similarly to T-cell lymphomas. Further pathologic assays suggested the histologic diagnosis of grade I lymphomatoid granulomatosis for all three evaluated specimens. After two years, patients treated with a combination of surgical resection and chemotherapy were disease free, supporting the efficacy of aggressive therapy in the management of this often mistreated group of lymphoid proliferations.
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