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  • Title: Complementation of the growth defect of an rnpA49 mutant of Escherichia coli by overexpression of arginine tRNA(CCG).
    Author: Kim MS, Park BH, Kim S, Lee YJ, Chung JH, Lee Y.
    Journal: Biochem Mol Biol Int; 1998 Dec; 46(6):1153-60. PubMed ID: 9891848.
    Abstract:
    We previously found that overexpression of arginine tRNA(CCG) from Brevibacterium albidum complements the rnpA49 mutation, which is responsible for the thermosensitivity of Escherichia coli RNase P function. In this present work, we show that the E. coli homologue tRNA also complements the same mutation, but other tRNAs do not. These results suggest that the rnpA49 mutation causes a major cellular defect in an RNase P reaction to generate the mature arginine tRNA(CCG).
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