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  • Title: Tyrosine phosphorylation and translocation of LAT in platelets.
    Author: Sarkar S.
    Journal: FEBS Lett; 1998 Dec 28; 441(3):357-60. PubMed ID: 9891970.
    Abstract:
    Platelet aggregation is accompanied by the tyrosine phosphorylation of several proteins including syk. However, some of these proteins are not identified. Recent studies showed that LAT is a syk substrate and is tyrosine phosphorylated during T cell stimulation. In this study, we demonstrated that LAT is present in platelets and is tyrosine phosphorylated in response to ADP- and thrombin-stimulated aggregation. Moreover, LAT, like syk and beta3, translocates to the cytoskeleton during the late stage of thrombin-stimulated irreversible aggregation and not during ADP-stimulated reversible aggregation.
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