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  • Title: Quantitative determination of domperidone in rat plasma by high-performance liquid chromatography with fluorescence detection.
    Author: Yamamoto K, Hagino M, Kotaki H, Iga T.
    Journal: J Chromatogr B Biomed Sci Appl; 1998 Dec 11; 720(1-2):251-5. PubMed ID: 9892090.
    Abstract:
    A sensitive and selective analytical method for the determination of domperidone in rat plasma is described. The procedure involves liquid-liquid extraction followed by reversed-phase high-performance chromatographic analysis with fluorometric detection at 282 nm for excitation and 328 nm for emission. The detection limit was 1 ng ml(-1) using 1 ml of plasma. This assay procedure should be useful for the pharmacokinetic study of domperidone in small animals such as rats.
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