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  • Title: Regulation of renin secretion by angiotensin II-AT1 receptors.
    Author: Kurtz A, Wagner C.
    Journal: J Am Soc Nephrol; 1999 Jan; 10 Suppl 11():S162-8. PubMed ID: 9892157.
    Abstract:
    Angiotensin II (AngII) resulting as the end product of a proteolytic cascade initiated by renin inhibits the secretion of renin in the sense of a negative feedback. A direct effect of AngII on renal juxtaglomerular epithelioid cells as the main source of renin secretion is mediated via AngII-AT1 receptors and involves calcium-dependent reactions. These reactions may comprise activation of protein kinase C and activation of chloride channels.
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