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  • Title: A new oral contraceptive based on the normophasic method.
    Author: Bolle J, Poulain A.
    Journal: Arzneimittelforschung; 1976; 26(3):441-3. PubMed ID: 989342.
    Abstract:
    62 women were treated for 554 cycles with normophasic oral contraceptive Fisioquens. A treatment cycle consists of 7 tablets of 0.05 mg ethinyloestradiol, followed by 15 tablets with a combination of 0.05 mg ethinyl-oestradiol and 1 mg lynestrenol. No pregnancies occurred. Both tolerance of the preparation and cycle control were good. Irregular bleeding occurred sporadically. Various side-effects diminished during treatment and even disappeared completely. Fisioquens appears to be a reliable contraceptive with a minimum of side-effects. A trial involved 62 women for over 554 cycles during which time a new normophasic oral contraceptive, Fisioquens, was administered. The preparation was tested with particular reference to the following parameters: contraceptive reliability, cycle control, frequency of possible side effects, and drug tolerance. A treatment cycle consisted of 7 tablets of .05 mg ethinyl estradiol followed by 15 tablets of a combination .05 mg ethinyl estradiol and 1 mg lynestrenol. Pregnancies were absent and irregular bleeding occurred sporadically. Various side effects diminished during treatment. The number of dropouts which could probably be attributed to the preparation itself was 4 (6.4%). These data indicate that Fisioquens appears to be a reliable contraceptive with a minimum number of side effects.
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