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  • Title: [Experimental studies on the mechanism of action of carbocromen on the isolated cat papillary muscle (author's transl)].
    Author: Bayer R, Rodenkirchen R, Kaufmann R.
    Journal: Arzneimittelforschung; 1976; 26(5):872-5. PubMed ID: 989360.
    Abstract:
    1. In isotonically shortening cat papillary muscle 3-(2-di-ethylaminoethyl)-4-methyl-7-(carbethoxy-methoxy)-2-oxo-1,2-chromene-hydrochloride (carbocromen; Intensain¿) (1-30 mug/ml) slightly increases contraction amplitude. 2. At low stimulation rates (6-12/min) the positive inotropic effect is more pronounced. 3. The maximal velocity of depolarization of the monophasic action potential is slightly reduced. 4. At all stimulation frequencies investigated (15-90/min) the total duration of the action potential -- especially at late repolarization level -- is strongly increased. Hence, functional refractory period is prolonged and maximal follow frequency reduced.
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