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  • Title: Acute effect of intravenous labetalol in the treatment of systemic arterial hypertension.
    Author: Ronne-Rasmussen JO, Andersen GS, Jensen NB, Andersson E.
    Journal: Br J Clin Pharmacol; 1976 Aug; 3(4 Suppl 3):805-8. PubMed ID: 990157.
    Abstract:
    1 The acute anti-hypertensive effect of intravenously administered labetalol, a combined alpha- and beta-adrenoreceptor antagonist, has been assessed in a pilot study involving 17 hypertensive patients. 2 In 11 patients with mild to moderately severe hypertension, there was a decrease in mean arterial pressure (24 mmHg) after a single intravenous dose of 50 mg labetalol. The peak response occurred approximately 4 min after administration of the drug. 3 In six patients with severe hypertension, there was a reduction in mean arterial pressure of 19 mmHg, but this was achieved after a further 50-mg dose administered 30 min after the initial injection. 4 In neither group was there any clinically significant decrease in heart rate, and drug-related side-effects were insignificant. 5 Labetalol reduced the blood pressure when administered intravenously and thus merits further investigation as a treatment for acute hypertensive crises.
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