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  • Title: Cardiovascular effects of labetalol during halothane anaesthesia.
    Author: Scott DB, Buckley FP, Drummond GB, Littlewoods DG, Macrae WR.
    Journal: Br J Clin Pharmacol; 1976 Aug; 3(4 Suppl 3):817-21. PubMed ID: 990159.
    Abstract:
    1 The circulatory effects of labetalol 25 mg intravenously in six patients during 1% halothane anaesthesia were studied. 2Labetalol caused a marked decrease in arterial pressure and a consistent but modest (20%) decrease in cardiac output. Heart rate was slowed and stroke volume did not change significantly. Central venous pressure increased and peripheral resistance decreased. 3 Increasing the halothane concentration of 3% led to marked myocardial depression as evidenced by reduced cardiac output and increased central venous pressure with increasing arterial hypotension. 4 Labetalol may be a suitable drug for controlling induced hypotension under general anaesthesia, although high concentrations of halothane should be used with care.
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