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  • Title: Simultaneous measurement of imipramine and desipramine by selected ion recording with deuterated internal standards.
    Author: Claeys M, Muscettola G, Markey SP.
    Journal: Biomed Mass Spectrom; 1976 Jun; 3(3):110-6. PubMed ID: 990418.
    Abstract:
    A gas chromatographic mass spectrometric method for the quantitative determination of imipramine and its N-demethylated metabolite desipramine in plasma samples at the nanogram level is reported. The method involves derivatization of the extracted drugs with trifluoroacetylimidazole, a mild derivatizing reagent. Specificity is provided by selected ion recording of the [M + H]+ ions, formed upon chemical ionization with methane as reagent gas. Quantitation is achieved by stable isotope dilution techniques, using deuterium labeled analogs, prepared by acid-catalyzed exchange, as internal standards. Data on patient samples are presented.
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