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  • Title: [Effect of liver damage in females on reactive changes in the livers of the progeny].
    Author: Tsirel'nikov NI.
    Journal: Biull Eksp Biol Med; 1976 Sep; 82(9):1114-6. PubMed ID: 990471.
    Abstract:
    The liver of 30-day ratlings was studied spectrocytophotometrically (glycogen, amino acid, RNA, and DNA content) and morphometrically (the size of the nuclei, nucleoli, mitotic index) 48 hours after the intragastric administration of CCI4; the mothers of these ratlings had sustained toxic hepatitis before pregnancy. The results obtained indicated that hepatitis sustained by the female animals not only influenced the morphological peculiarities and the histochemical properties of the liver of the progeny, but also largely conditioned the changes in the response of hepatocytes to the poison -- enhanced the damaging effect of the hepatotoxin.
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