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  • Title: [Telomeric chromosome fusion in cells treated with colcemid and 5-bromdeoxyuridine].
    Author: Stobetskii VI.
    Journal: Biull Eksp Biol Med; 1976 Sep; 82(9):1142-4. PubMed ID: 990480.
    Abstract:
    Specific chromosomes with two or more centromeres were found in the tetraploid metaphases of the second mitotic division after combined treatment with coldemid (0.05 mug/ml) and 5-bromodeoxyuridine (50 mug/ml) for 24 hours in the aneuploid Chinese hamster cell line. They were formed by telometric fusion of chromosomes and were absent in the cells treated with colcemid or 5-bromodeoxyuridine separately. A possible relation of this phenomenon to the telomeric association of chromosomes in the interphase nucleus, as well as to the chromosomal disturbances in the Louis Bar symdrome (ataxia -- telangiectasia) is discussed.
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