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  • Title: Phase I evaluation of dianhydrogalactitol (NSC-132313).
    Author: Haas CD, Stephens RL, Hollister M, Hoogstraten B.
    Journal: Cancer Treat Rep; 1976 May; 60(5):611-4. PubMed ID: 991150.
    Abstract:
    A toxicologic evaluation of dianhydrogalactitol in man was completed for a 5- and a 10-day schedule. The maximum tolerated dose was 30 mg/m2/day for the 5-day schedule and 21 mg/m2/day for the 10-day schedule. Dose-limiting myelosuppression occurred with both schedules, with leukopenia and thrombocytopenia being observed at median Days 15 and 19 respectively for the 5-day course and median Days 22 and 26 of the 10-day course. Nausea was infrequent and mild. Responses were obtained in one patient with laryngeal carcinoma and in one patient with adenocarcinoma of the lung.
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