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  • Title: Medium-frequency oscillations dominate the inspiratory nerve discharge of anesthetized newborn rats.
    Author: Kocsis B, Gyimesi-Pelczer K, Vertes RP.
    Journal: Brain Res; 1999 Feb 06; 818(1):180-3. PubMed ID: 9914455.
    Abstract:
    In this study we examined the synchronization of the discharge of phrenic and recurrent laryngeal motoneurons in anesthetized rat pups 14 to 36 days of age and kittens, 14-15 days old. We found that the inspiratory nerve activity consisted of synchronized bursts separated by 20-35 ms, corresponding to medium-frequency oscillations (MFO). Accordingly, the autospectra of the neurograms had two peaks, one at the respiratory rate and the other between 22. 8-43.0 Hz. No significant coherence was found between MFOs in the discharges of different nerves. High-frequency oscillations (HFO) characteristic for the adult inspiratory nerve activity were not present in the newborn rats. These findings demonstrate that phrenic nerve discharge of rat pups, like that of kittens and piglets, is in the MFO range, and suggest that MFO activity is an index of an early developmental stage of the respiratory system.
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