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  • Title: Specificity of immediate skin reaction with streptokinase-streptodornase (SK-SD) in humans.
    Author: Suzuki S, Kuroume T, Tomizawa S, Shibasaki M, Matsumura T.
    Journal: Clin Exp Immunol; 1976 Nov; 26(2):273-9. PubMed ID: 991458.
    Abstract:
    Streptokinase-streptodornase (SK-SD) induced immediate and delayed skin test reactions in a high proportion of patients with disorders in which beta-streptococcal infection may be involved. The P-K test and absorption experiments with antigen or anti-IgE suggested that the immediate reaction was mediated by specific IgE antibody against SK-SD. Furthermore, the ratio of specific IgE antibody against SK-SD to total IgE was roughly calculated to be 20 percent. Finally, the RAST technique was applied to detect specific IgE antibody against SK-SD which showed high radiocounts bound to SK-SD-coupled particles in the sera of nephrotic patients who had a strong immediate reaction against SK-SD and a severe disease state.
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