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  • Title: Pathogenesis of renal calculi in distal renal tubular acidosis. Possible role of parathyroid hormone.
    Author: Lee DB, Drinkard JP, Gonick HC, Coulson WF, Cracchiolo A.
    Journal: Clin Orthop Relat Res; 1976; (121):234-42. PubMed ID: 991509.
    Abstract:
    Elevated circulating levels of immunoreactive parathyroid hormone (PTH), hypercalciuria and renal calculi were found in 3 patients with distal renal tubular acidosis (RTA). Treatment with alkali resulted in a fall of PTH toward normal and a reduction in urinary calcium, but the frequency of urolithiasis was unchanged. In one patient in whom prolonged follow-up was possible, a subtotal parathyroidectomy was performed. This was followed by virtual cessation of stone formation despite persistence of the acidification defect. This study suggests that RTA may be associated with secondary hyperparathyroidism and that the consequent elevation in PTH may play a contributory role in the pathogenesis of renal calculi.
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