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  • Title: Antimicrobial peptides of the brevinin-2 family isolated from gastric tissue of the frog, Rana esculenta.
    Author: Wang Y, Knoop FC, Remy-Jouet I, Delarue C, Vaudry H, Conlon JM.
    Journal: Biochem Biophys Res Commun; 1998 Dec 30; 253(3):600-3. PubMed ID: 9918774.
    Abstract:
    Four structurally related peptides with potent growth-inhibitory activity towards Escherichia coli were isolated from an extract of the stomach of the European green frog Rana esculenta, and were identified as members of the brevinin-2 family. Two peptides, termed brevinin-2Eg (GIMDTLKNLA10 KTAGKGALQS20 LLNHASCK LS30GQC) and brevinin-2Eh (GIMDTLKNLA10 KTAGKGALQS20 LLNHASCKL S30 KQC) have not been described previously. One peptide is identical to brevinin-2Ec, previously isolated from R. esculenta skin secretions, and one peptide is identical to brevinin-2Ef whose structure has been deduced from a cloned cDNA prepared from a R. esculenta skin cDNA library. The data demonstrate that certain peptides of the brevinin-2 family, like the magainins in the toad, Xenopus laevis, may play an important role in protecting the gastrointestinal tract of Ranid frogs against microbial invasion.
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