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Pubmed for Handhelds

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  • Title: Restoration of self-stimulation inhibited by neuroleptics.
    Author: Wauquier A, Niemegeers CJ.
    Journal: Eur J Pharmacol; 1976 Nov; 40(1):191-4. PubMed ID: 991925.
    Abstract:
    Pimozide-induced inhibition of lever-pressing for brain stimulation in the lateral hypothalamic area was differentially restored by the centrally acting anticholinergic, dexetimide and by different dopaminergic drugs. In addition, a differential antagonism towards chlorpromazine-induced inhibition of self-stimulation was shown. The results indicate that anticholinergis (non-competitive antagonism) or drugs which enhance endogenous neuro-transmission by increased release or by uptake blockade (competitive antagonism) are able to reserve the neuroleptic-induced inhibition of self-stimulation more effectively than are receptor agonists.
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