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  • Title: Sequential histopathological and biochemical events in rat caput epididymis after alpha monochlorohydrin administration.
    Author: Kalla NR, Chohan KS.
    Journal: Exp Pathol (Jena); 1976; 12(1):19-24. PubMed ID: 991962.
    Abstract:
    This paper presents sequential histological, histochemical and biochemical changes in rat caput epididymis after a single 100 mg/kg oral dose of alpha chlorohydrin. Desquamation of caput epithelium occurs as early as two days after drug treatment. The caput epididymis is blocked because of accumulation of testicular fluid containing exfoliated immature testicular cells and caput epithelium. There was no effect of drug on motility and morphology of spermatozoa examined from different segments of epididymis and vas deferens. Marked decrease in acid and alkaline phosphatases, nucleic acids and proteins have been registered after drug treatment. On the contrary increase in SDH, cholesterol and glycogen was observed after drug treatment. Decrease in phospholipids in initial stages has also been observed. The histological, histochemical, and biochemical effects of a single 100 mg/kg oral dose of alpha-chlorohydrin on the caput epididymis of the rat were studied. Within 2 days of treatment, evidence of desquamation of the caput epithelium became apparent. The accumulation of testicular fluid, which contained exfoliated immature testicular cells and caput epithelium, caused blockage of the caput epididymis. However, spermatoz oa recovered from different regions of the epididymis and vas deferens did not exhibit altered motility or morphology. The treatment was associated with a decrease in caput epididymal content of acid alkaline phosphatases, nucleic acids and proteins, and an increase in SDH, cholesterol, and glycogen. Phospholipids were also decreased during the early stages after treatment. The results are discussed in relation to previous explanations of the mechanism of action of alpha-chlorohydrin.
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