These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Photoprotection: sunscreens and the immunomodulatory effects of UV irradiation.
    Author: Finlay-Jones JJ, Hart PH.
    Journal: Mutat Res; 1998 Nov 09; 422(1):155-9. PubMed ID: 9920440.
    Abstract:
    UV-B irradiation (UVR) of the host, in both humans and animal models, induces dose-related acute and chronic changes in skin which include erythema and photoageing, and induction of cancer. It can also induce modulation of immune responses of the host to antigens presented following irradiation. Commercially-available, broad-spectrum, high SPF (15, 15 + ) sunscreens protect against most effects of UV irradiation. An exception is the effects of UVR on immune responsiveness, with varying degrees of protection having been reported. We examined a system of UV-induced systemic suppression of contact hypersensitivity (CHS) responses in BALB/c mice. A range of commercially-available, broad spectrum, high SPF (15 + ) sunscreens demonstrated at best partial protection against systemic immunosuppression, yet were able to protect against two hallmarks of acute UVR-induced damage: skin oedema and keratinocyte proliferation. Two major models have been identified for the induction of immunosuppression following UVR, one identifying trans-urocanic acid (trans-UCA; deaminated histidine, located in the stratum corneum) as the critical photoreceptor, the other featuring DNA. UVR of trans-UCA produces cis-UCA, which itself is immunomodulatory. There was some abrogation of trans to cis isomerisation of urocanic acid in UV-irradiated, sunscreen-protected mice. However, the majority of the immunomodulation seen in these mice was abrogated by pretreatment with a monoclonal antibody to cis-urocanic acid. It is possible to induce formation of cis-urocanic acid in BALB/c skin in the absence of immunosuppression, using lower doses of UV radiation, indicating that formation of cis-urocanic acid in the stratum corneum is not necessarily sufficient to induce immunosuppression in the UV-irradiated host. The mechanisms of induction of the immunomodulated state in the UV-irradiated host are potentially diverse and the subject of ongoing debate. Our studies maintain a role for cis-UCA, and form the basis for further studies on its involvement in immunomodulation by UVR in sunscreen-protected hosts.
    [Abstract] [Full Text] [Related] [New Search]