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  • Title: Roles of acetyl-CoA carboxylase beta in muscle cell differentiation and in mitochondrial fatty acid oxidation.
    Author: Lee JK, Kim KH.
    Journal: Biochem Biophys Res Commun; 1999 Jan 27; 254(3):657-60. PubMed ID: 9920796.
    Abstract:
    Acetyl-CoA carboxylase beta is expressed primarily in heart and skeletal muscle, where it may play a role in the control of mitochondrial fatty acid uptake and oxidation by controlling carnitine-palmitoyl-CoA transferase 1. To investigate the relationship between ACC-beta expression and myoblast differentiation, we specifically blocked ACC-beta production by expressing an antisense gene to the specific N-terminal region of ACC-beta in H9c2 cells. The expression of the antisense ACC-beta mRNA retarded cell fusion, myosin formation, and creatine kinase induction; all of these parameters are hallmarks of muscle cell differentiation. On the other hand, the rate of fatty acid oxidation was not affected by the presence or absence of ACC-beta in the cells.
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