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  • Title: [Platelet function].
    Author: Mitrović S, Mitrović D, Todorović V, Videnović A.
    Journal: Srp Arh Celok Lek; 1998; 126(11-12):478-87. PubMed ID: 9921023.
    Abstract:
    Platelets are cells which possess broad potential activities in the area of both physiological functions and physiological disorders. The role of platelets in haemostasis with vascular injury is well documented. With vascular and endothelial cell injury, the following sequence of platelet events includes: adhesion, aggregation, secretion. In addition, platelets have a certain role in formation of a permanent haemostatic plug and prolongation of the period of vasoconstriction. There is also the recent evidence of the role of platelets in haemostasis without vessel wall injury. It is evident that platelets play the essential role not only in normal haemostasis but also in wound healing, maintenance of normal plasma homeostasis by endocytosis as well as in inflammation. Platelets play a role in the following pathological events: atherosclerosis, tissue fibrosis, tromboembolism, graft rejection, cancer metastasis. A complete insight into the content of platelet depot organelles, and their functional possibilities requires further research in this area.
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