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  • Title: [Effect of thyroxine and 2,4-dinitrophenol on cardiac energetics].
    Author: Aliukhin IuS.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1976 Aug; 62(8):1182-9. PubMed ID: 992140.
    Abstract:
    The administrations of 1-thyrohine (20 mg/kg) for two sucessive daysin the rats or 10(-3) M 2,4-dinitrophenol (2,4-DNP) in vitro reduced the mechanical of the heart in working isolated preparations of the rat heart. Oxygen consumption of inactive heart did not react to thyroxine and significantly increased after 2,4-DNP administration. The reduction of the heart efficiency due to thyroxine is, probably, associated with a decreased efficiency of mechanochemical conjugation in the myocardium muscular fibers.
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