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  • Title: Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors.
    Author: Miyoshi H, Smith KA, Mosier DE, Verma IM, Torbett BE.
    Journal: Science; 1999 Jan 29; 283(5402):682-6. PubMed ID: 9924027.
    Abstract:
    Efficient gene transfer into human hematopoietic stem cells (HSCs) is an important goal in the study of the hematopoietic system as well as for gene therapy of hematopoietic disorders. A lentiviral vector based on the human immunodeficiency virus (HIV) was able to transduce human CD34+ cells capable of stable, long-term reconstitution of nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice. High-efficiency transduction occurred in the absence of cytokine stimulation and resulted in transgene expression in multiple lineages of human hematopoietic cells for up to 22 weeks after transplantation.
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