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  • Title: Pseudomembranous colitis associated with antibiotics.
    Author: Medline A, Shin DH, Medline NM.
    Journal: Hum Pathol; 1976 Nov; 7(6):693-703. PubMed ID: 992648.
    Abstract:
    Colitis associated with antibiotics, particularly with lincomycin and clindamycin, is a well established entity. The colitis may be clinically and radiologically very difficult to distinguish from inflammatory bowel disease, including Crohn's disease and ulcerative colitis. A wide spectrum of pathological features is described with various antibiotics. However, the pathological picture in the pseudomembranous form is quite distinctive. The most important histological findings include a "mushroom-like" or "explosive" appearance of the pseudomembrane with a sudden transition to normal mucosa adjacent to the lesion. Rectal biopsy is both an accurate and a rapid method of establishing the diagnosis.
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