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  • Title: CD48-deficient mice have a pronounced defect in CD4(+) T cell activation.
    Author: González-Cabrero J, Wise CJ, Latchman Y, Freeman GJ, Sharpe AH, Reiser H.
    Journal: Proc Natl Acad Sci U S A; 1999 Feb 02; 96(3):1019-23. PubMed ID: 9927686.
    Abstract:
    We have generated mice deficient in the expression of the lymphocyte cell surface antigen CD48 (Blast-1, BCM1, sgp-60) by gene targeting in embryonic stem cells. Mice homozygous for the CD48 mutation (CD48(-/-) mice) are severely impaired in CD4(+) T cell activation. Proliferative responses to mitogens, anti-CD3 mAb, and alloantigen are all reduced. Experiments in which T cells and antigen-presenting cells from either wild-type or CD48(-/-) mice were cocultured reveal that CD48 is important on both T cells and antigen-presenting cells. The most dramatic impairment was observed in experiments in which highly purified T cells were stimulated through the T cell receptor in the presence of the phorbol ester, phorbol 12-myristate 13-acetate. The results of these experiments raise the possibility that CD48 plays a role in signaling through the T cell receptor.
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