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  • Title: p22/PACAP response gene 1 (PRG1): a putative target gene for the tumor suppressor p53.
    Author: Schäfer H, Trauzold A, Sebens T, Deppert W, Fölsch UR, Schmidt WE.
    Journal: Ann N Y Acad Sci; 1998 Dec 11; 865():27-36. PubMed ID: 9927993.
    Abstract:
    In this study we describe a novel putative p53-responsive gene, designated p22/PACAP response gene 1 (PRG1), recently identified as a proliferation-associated early-response gene in rats. By means of electrophoretic mobility shift assay and CAT-reporter gene assay, we could demonstrate that the p53 binding site residing in the promoter of p22/PRG1 is functional in vitro. Furthermore, in clone 6 cells expression of p22/PRG1 is induced in parallel to p21/Waf1 under conditions permitting mutant p53 to adopt wild-type configuration. An increase of p22/PRG1 transcription was also observed in gamma-irradiated rat splenocytes, which undergo p53-dependent apoptosis. Our findings demonstrate that p22/PRG1 fulfills all essential criteria as a p53 target gene and might be implicated in p53-dependent apoptosis.
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