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  • Title: Recovery of locomotion following transplantation of monoaminergic neurons in the spinal cord of paraplegic rats.
    Author: Gimenez y Ribotta M, Orsal D, Feraboli-Lohnherr D, Privat A.
    Journal: Ann N Y Acad Sci; 1998 Nov 16; 860():393-411. PubMed ID: 9928327.
    Abstract:
    Severe traumatic lesions of the spinal cord yield a permanent deficit of motricity in adult mammals and specifically a loss of locomotor activity of hindlimbs when the lesion is located at the lower thoracic level. To restore this function, we have developed a paradigm of transplantation in rats based on a transection model of the spinal cord and the subsequent injection at the sublesional level of a suspension of embryonic brainstem monoaminergic neurons which play a key role in the modulation of locomotion. A genuine locomotion was characterized in transplanted animals by electromyographic and electroneurographic recordings. This correlated with a specific reinnervation pattern of targets, where typical synapses were found, and with the normalization of biochemical parameters.
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