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  • Title: Responses to monosodium glutamate and guanosine 5'-monophosphate in rat fungiform taste cells.
    Author: Lin W, Kinnamon SC.
    Journal: Ann N Y Acad Sci; 1998 Nov 30; 855():407-11. PubMed ID: 9929633.
    Abstract:
    Monosodium glutamate (MSG) elicits a unique taste sensation called umami. The umami sensation is potentiated by the presence of 5'-ribonucleotides such as guanosine 5'-monophosphate (5'-GMP). We have used giga-seal whole cell recording to examine glutamate transduction in individual cells of isolated rat fungiform taste buds. Approximately 56% of fungiform taste cells responded to bath application of glutamate. Three types of responses occurred: decrease in inward holding current; increase in inward holding current; and a biphasic response, with an increase followed by a decrease in holding current. Similar responses were observed in response to 5'-GMP. Further, responses to 5'-GMP may occur in cells that are glutamate-insensitive, suggesting that different receptors mediate the transduction of glutamate and 5'-GMP. Simultaneous bath application of glutamate and 5'-GMP resulted in a synergistic response in some taste cells.
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