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  • Title: Activity-rest stimulation of latissimus dorsi for cardiomyoplasty: 1-year results in sheep.
    Author: Arpesella G, Carraro U, Mikus PM, Dozza F, Lombardi P, Marinelli G, Zampieri S, El Messlemani AH, Rossini K, Pierangeli A.
    Journal: Ann Thorac Surg; 1998 Dec; 66(6):1983-90. PubMed ID: 9930481.
    Abstract:
    BACKGROUND: In dynamic cardiomyoplasty electro-stimulation achieves full transformation of the latissimus dorsi (LD); therefore, its slowness limits the systolic support. Daily activity-rest could maintain partial transformation of the LD. METHODS: Sheep LD were burst-stimulated either 10 or 24 hours/day. Before and 2, 4, 6, and 12 months after stimulation, LD power output, fatigue resistance, and tetanic fusion frequency were assessed. Latissimus dorsi were biopsied at 6 months, and sheep sacrificed at 12 months. RESULTS: After 1 year of 10 hours/day stimulation LD was substantially conserved and contained large amounts of fast type myosin. From 2 months to 1 year of stimulation the power per muscle of the daily rested LD was greater than that of the left ventricle, being three to four times higher than in the 24-hour/day stimulation. CONCLUSIONS: If extended to humans, these results could be the rationale for the need of a cardiomyostimulator, whose discontinuous activity could offer to patients the long-standing advantage of a faster and powerful muscle contraction.
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