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  • Title: [Multicenter phase II study of the Liver Metastases Study Group of weekly intra-arterial 24-hour high dose therapy with 5-FU and folinic acid (FA) in liver metastases of colorectal tumors].
    Author: Staib-Sebler E, Müller HH, Mattes P, Junginger T, Saeger HD, Lorenz M.
    Journal: Langenbecks Arch Chir Suppl Kongressbd; 1998; 115():1441-4. PubMed ID: 9931906.
    Abstract:
    This prospective multicenter trial was performed to determine the response rate, toxicity and applicability of continuous 24 h hepatic arterial infusion of high-dose 5-FU and folinic acid. An improved response rate (60.5% in non-pretreated patients) was however associated with many systemic side-effects (340/509), mainly nausea and diarrhea. Therefore this treatment should be applied only in selected patients in specialized centers.
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